Nice Knuckles

Nice Knuckles is a Hard Wax Balm for Growing Knuckles

The selected Nice Knuckles components were chosen because there are individually published papers on their down regulatory effects on the cytokines* or on their cellular health support . 

The Nice Knuckles combination has been put together towards Two goals:
- to reduce the excess cytokine signaling

- to support the cells & tissues in your knuckles

Collagen Peptides, Vitamin D3, Horsetail Reed, White Willow Bark, Green Tea Extract, Hemp Extract, Cannabichromene, Tocopherol (Vitamin E), Peppermint Extract.

• Collagen Peptides:
  • Collagen peptides primarily support joint health by providing essential amino acids needed for collagen synthesis. While they may not directly reduce cytokines, they contribute to overall joint integrity and may indirectly help mitigate inflammation by supporting joint structure.
• Vitamin D:
  • Vitamin D has immunomodulatory effects and may help reduce inflammation by inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6.
• White Willow Bark:
  • White willow bark contains salicin, a compound similar to aspirin, which may help reduce inflammation and pain. It may inhibit the production of pro-inflammatory cytokines such as TNF-α and IL-1β.
• Horsetail Reed:
  • There's limited research on the effects of horsetail reed on cytokines associated with arthritis. However, its high silica content may support joint health by promoting collagen formation and tissue repair.
• Green Tea Extract:
  • Green tea extract contains polyphenols, particularly epigallocatechin gallate (EGCG), which have anti-inflammatory properties. EGCG may help reduce the production of pro-inflammatory cytokines such as TNF-α and IL-6.
• Hemp Extract:
  • Hemp extract has been studied for their anti-inflammatory effects and may modulate cytokine production, including reducing levels of TNF-α and IL-6.
• Cannabichromene (CBC): 
  • CBC may also influence cytokines involved in inflammation, potentially reducing TNF-α, IL-6 and IL-1β levels. 
• Tocopherol (Vitamin E):
  • Tocopherol, a form of vitamin E, has antioxidant properties that may help reduce inflammation by scavenging free radicals. While it may not directly target cytokines, its antioxidant effects can help mitigate oxidative stress associated with inflammation.
• Peppermint Extract:
  • Peppermint extracts are made up of 30% menthol, which has cooling and analgesic properties that can help alleviate pain associated with inflammation. While it may not directly target cytokines, it can provide symptomatic relief.

It's important to note that while these natural botanicals and nutrients may have anti-inflammatory effects and potentially modulate cytokine production, individual responses can vary. Additionally, scientific research on the specific effects of these substances on cytokines in the context of rheumatoid arthritis is on-going, and more studies are needed to fully understand their mechanisms of action in this condition.